Beilstein J. Org. Chem.2021,17, 2642–2649, doi:10.3762/bjoc.17.177
experiments reveal that the presence of a β-silyl group in the enones is crucial for high reactivity under the optimized reaction conditions.
Keywords: β-silyl α,β-unsaturated carbonyl compounds; β-silyl nitroalkanes; chiralorganosilanes; organocatalysis; solvent-free synthesis; Introduction
organosilanes [2][7][8][9][10][11][12][13][14]. A number of efficient catalytic enantioselective methods has been developed for the synthesis of chiralorganosilanes [15][16][17][18][19][20][21][22][23][24]. Out of the chiralorganosilanes, nitrosilanes are important synthetic targets as they are precursors of
nucleophiles to β-silyl α,β-unsaturated carbonyl compounds were documented as one of the straightforward and atom-economic approaches for the facile synthesis of chiralorganosilanes (Scheme 1c–f) [30][31][32][33]. Recently, the aforementioned reaction under organocatalytic conditions has gained attention [34
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Graphical Abstract
Scheme 1:
Selected methods for the synthesis of enantioenriched β-silyl nitroalkanes, synthesis of chiral org...